Circadian Biology: Fibroblast Clocks Keep Ticking
نویسنده
چکیده
Real-time cellular imaging of gene expression has revealed that fibroblasts contain a robust, self-sustained and cell-autonomous circadian oscillator, with a range of properties that both overlap and contrast with those of the neural clock of the suprachiasmatic nuclei.
منابع مشابه
Circadian Clocks: Timely Interference by MicroRNAs
Transcriptional/post-translational feedback loops have dominated ideas about how circadian clocks are able to keep time. An entirely new level of feedback regulation -- post-transcriptional regulatory microRNAs -- has now been added to the circadian mix.
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Although overt diurnal rhythms of behavior do not begin until well after birth, molecular studies suggest that the circadian clock may begin much earlier at a cellular level: mouse embryonic fibroblasts, for example, already possess robust clocks. By multiple criteria, we found no circadian clock present in mouse embryonic stem cells. Nevertheless, upon their differentiation into neurons, circa...
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عنوان ژورنال:
- Current Biology
دوره 15 شماره
صفحات -
تاریخ انتشار 2005